Table 2.
AAA genetic loci discovered using genome-wide association studies.
| Chromosomal location (study) | Nearest gene (gene symbol; gene ID) |
Polymorphism | RAF | OR [95% CI] |
Association P valuea |
|---|---|---|---|---|---|
| 3p12.3 [42] | Contactin-3 (CNTN3; 5067) |
rs7635818 | 0.42 | 1.33 [1.10–1.21] |
0.0028 |
| 9p21.3 [44] | CDKN2B antisense RNA 1 (CDKN2BAS1; 100048912) |
rs10757278 | 0.45 | 1.31 [1.22–1.42] |
1.2 × 10−12 |
| 9q33.1 [43] | DAB2 interacting protein (DAB2IP; 153090) |
rs7025486 | 0.25 | 1.21 [1.14–1.28] |
4.6 × 10−10 |
| 12q13.3 [45] | Low density lipoprotein receptor-related protein 1 (LRP1; 4035) |
rs1466535 | 0.68 | 1.15 [1.10–1.21] |
4.5 × 10−10 |
| 19p13.2 [41] | Low density lipoprotein receptor (LDLR; 3949) | rs6511720 | 0.88 | 0.76 [0.70–0.83] |
2.1 × 10−10 |
RAF: risk allele frequency in population; OR: odds ratio; 95% CI: 95% confidence interval; rs number: unique identifier for each single nucleotide polymorphism (for more information, see http://www.ncbi.nlm.nih.gov/snp/).
Gene symbols and IDs are available from http://www.ncbi.nlm.nih.gov/gene/.
a P values were taken from the first report demonstrating association with AAA and cited in the first column.
Modified from [4].