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Number of significant covariates versus tender point count (TPC) thresholds, varying between 1 and 17 and with the pain response cutoff set at 2 at the tender point examination. Analyzed in the univariate/marginal model a large number of variables linked to pain and pain-related functional interference (summarized in Table 4) appeared as consistently significant explanatory factors from a TPC threshold at 8, indicating a perturbation of clinical disease severity at this threshold.
