Table 2.

Influence of HLA-G polymorphism on susceptibility to infectious diseases.

Pathogens	Protection	Susceptibility	Vertical transmission (mother-to-child)	References
HIV	HLA-G*0105N (null allele)			[72, 73]
		G*010108 allele G*010108/010401 G*010101/010108		[72]
		G*0105N 14 bp (ins) allele +3142G (insG) haplotype		[74] [75] [75]
	G*01:01:01 genotype	G*01:04:04 genotype		[122]
			Differences in the HLA-G gene DNA sequence between mother and child	[76]
		14 bp insertion allele 14 bp + 3142G (insG) haplotype		[75]
		insG/insG diplotype in HCV coinfected		[75]
HCV		insG/insG diplotype in HIV coinfected		[75]
	+3142C allele in sickle cell disease patients			[79]
		−14 bp/−14 bp genotype		[81]
	HLA-G*0105N		G*010401 homozygosity for HLA-G 14 bp deletion	[80]
HPV	14 bp ins allele	14 bp del allele del/C haplotype with ICC development		[82]
Plasmodium falciparum	+3187G allele and haplotype UTR1	Haplotype UTR3		[83]
	+3010G and +3142C +3010G and +3196G			[49]