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. 2014 Jan 15;8(3):565–580. doi: 10.1016/j.molonc.2014.01.004

Figure 1.

Figure 1

Honokiol inhibits invasion and migration of breast cancer cells. A, MCF7 and MDA‐MB‐231 cells were cultured in matrigel‐invasion chambers followed by treatment with 5 μM honokiol (HNK) for 24 h as indicated. C represents vehicle controls. The number of cells that invaded through the matrigel was counted in five different regions. *P < 0.005, compared with untreated controls. B, MCF7 and MDA‐MB‐231 cells were subjected to spheroid‐migration assay. Culture media were replaced with media containing honokiol (5 μM) or vehicle control media (C). The spheroids were photographed at 24 h, 48 h and 72 h‐post treatment. The results shown are representative of three independent experiments performed in triplicates.