Table 1.

Clinical observations of dogs vaccinated with virus-like particle (VLP) vaccine and infected with canine influenza virus (CIV).

Group	No. of animals	Clinical signs
		1 day post challenge	2 day post challenge	3 day post challenge	4 day post challenge
Non-vaccinated	1	–	OD, AN, DE	AN, DE, CO	AN, DE, CO
	2	–	OD, AN, DE	AN, DE, ND	AN, DE, ND
	3	–	OD, AN, DE	AN, DE	AN, DE, ND
3.75 μg vaccinated	4	–	–	–	–
	5	–	–	–	–
	6	–	–	–	–
7.5 μg vaccinated	7	–	–	–	–
	8	–	–	–	–
	9	–	–	–	–
15 μg vaccinated	10	–	–	–	–
	11	–	–	–	–
	12	–	–	–	–

OD, ocular discharge; AN, anorexia; DE, depression; CO, cough; ND, nasal discharge.