Table 1.

	TLR4 Haplotype
Parameter	wt/wt N=103	299/wt, wt/399 or 299/399 SNP N=10	P
Baseline Characteristics
age	57 (46-67)	46 (42-64)	0.31
gender (female)	33 (32%)	5 (50%)	0.25
Medical History
AF	16 (16%)	0 (0%)	0.18
CHD	26 (25%)	1 (10%)	0.28
DM	23 (22%)	4 (40%)	0.21
HTN	53 (51%)	7 (70%)	0.26
smoker	40 (39%)	2 (20%)	0.24
HLD	74 (72%)	7 (70%)	0.90
Clinical/Radiological Data on Patients’ Stroke
initial NIHSS score	11 (4-20)	9 (3-18)	0.46
initial infarct volume (cc)	12 (2-90)	12 (0.1-117)	0.46
Stroke Etiology
lacunar	8 (8%)	3 (30%)	0.02
cardioembolic	30 (29%)	0 (0%)	0.046
large artery atherosclerosis	16 (16%)	1 (10%)	0.64
dissection	6 (6%)	1 (10%)	0.60
Other#	21 (20%)	2 (20%)	0.76
unknown	22 (21%)	3 (30%)	0.53
Infections
all infections	26 (25%)	3 (30%)	0.76
PNA	12 (12%)	0 (0%)	0.33

AF=atrial fibrillation, CHD=coronary heart disease, DM=diabetes mellitus, HTN=hypertension, HLD=hyperlipidemia, NIHSS=National Institutes of Health Stroke Scale, PNA=pneumonia, wt=wild type, SNP=single nucleotide polymorphism.

NS = p>0.20,

^#Other etiology category included 1 iatrogenic, 3 paradoxical emboli and 19 with either multiple competing etiologies or uncertain etiology