Table 3.
Markers of inflammation from AIS onset to 3 months in patients who either had or did not have one of the variant TLR4 SNP haplotypes under investigation here (299/wt, wt/399 or 299/399): indicated in table as “+SNP”. Data values shown are medians (interquartile range). P values are adjusted for stroke severity.
| Time: | 72 hours | 1 week | 1 month | 3 months | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| wt/wt | +SNP | P | wt/wt | +SNP | P | wt/wt | +SNP | P | wt/wt | +SNP | P | |
|
WBCs
(thou/microL) |
7.44
(5.99, 10.00) |
8.97
(7.68, 12.42) |
0.025 |
7.66
(6.02, 9.78) |
10.70
(7.46, 13.00) |
0.003 | 6.53 (5.34, 8.54) |
8.43 (6.82, 11.15) |
0.074 | 6.88 (5.42, 8.12) |
7.99 (7.41, 10.10) |
0.139 |
|
PMNs
(thou/microL) |
5.04
(3.44, 6.87) |
6.08
(5.06, 8.06) |
0.023 | 4.80 (3.36-6.44) |
5.49 (3.95, 8.26) |
0.104 | 4.12 (3.00, 5.43) |
5.18 (4.22-7.33) |
0.087 | 3.89 (3.00, 5.43) |
5.48 (4.10, 7.30) |
0.059 |
|
lymphs
(thou/microL) |
1.47 (1.22, 1.82) |
1.71 (1.42, 1.94) |
0.755 | 1.80 (1.40-2.25) |
1.80 (1.69, 2.13) |
0.918 | 1.78 (1.27-2.04) |
1.96 (1.63, 2.45) |
0.175 | 1.73 (1.34, 2.14) |
1.83 (1.41, 2.59) |
0.468 |
|
monos
(thou/microL) |
0.64 (0.46, 0.86) |
0.61 (0.46, 0.82) |
0.742 | 0.66 (0.50, 0.89) |
0.68 (0.58, 1.04) |
0.363 | 0.52 (0.42, 0.68) |
0.50 (0.47, 0.60) |
0.727 | 0.50 (0.41, 0.65) |
0.59 (0.52, 0.67) |
0.127 |
|
CRP
(mg/L) |
9.5 (2.6, 48.1) |
8.8 (1.9, 87.1) |
0.208 | 7.20 (2.20, 25.95) |
8.20 (3.85, 48.65) |
0.811 | 2.70 (0.95, 9.15) |
4.00 (0.95-10.92) |
0.900 |
1.90
(0.60, 5.90) |
2.50
(0.90, 12.00) |
0.002 |
|
IL-6
(pg/mL) |
1.94 (nd, 7.23) |
1.66 (nd, 15.16) |
0.941 | 1.26 (nd, 4.39) |
2.87 (1.47, 4.83) |
0.999 | nd (nd, 2.12) |
nd (nd, 2.52) |
0.817 | nd (nd, 1.62) |
1.41 (nd, 1.69) |
0.611 |
|
IL-10
(pg/mL) |
nd (nd, 0.93) |
nd (nd, nd) |
0.182 | nd (nd, 0.75) |
nd (nd, 0.56) |
0.519 | nd (nd, 0.70) |
nd (nd, nd) |
0.301 | nd (nd, 0.70) |
nd (nd, nd) |
0.369 |
|
TNFα
(pg/mL) |
1.87 (nd, 2.96) |
nd (nd, 4.05) |
0.669 | 2.12 (nd, 3.92) |
nd (nd, 4.72) |
0.069 | 1.88 (nd, 3.89) |
2.18 (nd, 4.30) |
0.519 | 1.98 (nd, 3.26) |
1.76 (nd, 4.77) |
0.827 |
|
IL-1ra
(pg/mL) |
1645 (998, 2946) |
2401 (765, 4137) |
0.094 |
1777
(981, 3189) |
2086
(1458, 8401) |
0.009 | 1400 (812-3214) |
2029 (1448, 3150) |
0.272 | 1009 (579, 1745) |
1238 (606, 2579) |
0.982 |
SNP=single nucleotide polymorphism, AIS=acute ischemic stroke, WBCs=white blood cells, PMNs=polymorphonuclear cells, monos = monocytes, lymphs=lymphocytes, CRP=high sensitivity C reactive protein, IL=interleukin, TNF=tumor necrosis factor, IL-1ra=IL-1 receptor antagonist, wt=wild type, , nd=not detected, NS=P>0.20, P=p-value (adjusted for initial stroke severity) for comparisons between wt/wt haplotype vs. either the 299/wt, wt/399 or 299/399 haplotypes.