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. 2014 May 7;20(17):5008–5016. doi: 10.3748/wjg.v20.i17.5008

Figure 1.

Figure 1

Pathogenic mutation within the nucleotide-binding oligomerisation domain 2/caspase recruitment domains 15 gene. A: Physical map of the exon-intron organization of the nucleotide-binding oligomerisation domain 2/caspase recruitment domains 15 (NOD2/CARD15) gene and the approximate positioning of the mutations within the gene; B: Structural domain of the NOD2/CARD15 gene. Like the other members of the NOD/leucine rich repeat domain (LRR) protein family, NOD2/CARD15 consists of three distinct functional domains: CARD, a centrally located NOD and a LRR.