Table 3.
Distribution of the microsomal epoxide hydrolase p.His139Arg genotypes in controls and esophageal cancer patients
| Variable | Studies | Cases/controls | OR (95%CI) | P value | P for heterogeneity | I2 | Model |
| Arg/His vs His/His | |||||||
| Total | 6 | 861/1571 | 1.02 (0.84-1.23) | 0.869 | 0.176 | 34.8 | F |
| Caucasian | 2 | 405/676 | 0.97 (0.74-1.27) | 0.824 | 0.955 | 0.0 | F |
| Asian | 4 | 456/895 | 1.09 (0.69-1.73) | 0.709 | 0.060 | 59.4 | R |
| ESCC | 5 | 547/1319 | 0.99 (0.67-1.46) | 0.954 | 0.052 | 57.5 | R |
| EADC | 2 | 314/676 | 1.05 (0.79-1.40) | 0.718 | 0.755 | 0.0 | F |
| PB | 5 | 805/1476 | 1.02 (0.84-1.24) | 0.833 | 0.106 | 47.5 | F |
| HB | 1 | 56/95 | 0.95 (0.47-1.91) | NA | NA | NA | NA |
| Arg/Arg vs His/His | |||||||
| Total | 6 | 861/1571 | 0.96 (0.60-1.54) | 0.855 | 0.206 | 30.6 | F |
| Caucasian | 2 | 405/676 | 0.61 (0.31-1.21) | 0.158 | 0.308 | 3.9 | F |
| Asian | 4 | 456/895 | 1.59 (0.80-3.16) | 0.184 | 0.324 | 13.6 | F |
| ESCC | 5 | 547/1319 | 1.28 (0.72-2.30) | 0.402 | 0.346 | 10.6 | F |
| EADC | 2 | 314/676 | 0.60 (0.28-1.27) | 0.178 | 0.313 | 1.8 | F |
| PB | 5 | 805/1476 | 1.08 (0.66-1.76) | 0.765 | 0.251 | 25.5 | F |
| HB | 1 | 56/95 | 0.22 (0.03-1.90) | NA | NA | NA | NA |
| Arg/Arg + Arg/His vs His/His | |||||||
| Total | 6 | 861/1571 | 1.03 (0.78-1.37) | 0.810 | 0.095 | 46.6 | R |
| Caucasian | 2 | 405/676 | 0.92 (0.71-1.20) | 0.555 | 0.719 | 0.0 | F |
| Asian | 4 | 456/895 | 1.14 (0.71-1.81) | 0.593 | 0.042 | 63.5 | R |
| ESCC | 5 | 547/1319 | 1.02 (0.68-1.53) | 0.918 | 0.028 | 63.1 | R |
| EADC | 2 | 314/676 | 1.00 (0.75-1.31) | 0.976 | 0.550 | 0.0 | F |
| PB | 5 | 805/1476 | 1.07 (0.78-1.48) | 0.676 | 0.062 | 55.5 | R |
| HB | 1 | 56/95 | 0.82 (0.42-1.62) | NA | NA | NA | NA |
| Arg/Arg vs Arg/His + His/His | |||||||
| Total | 6 | 861/1571 | 0.97 (0.61-1.56) | 0.911 | 0.247 | 25.0 | F |
| Caucasian | 2 | 405/676 | 0.62 (0.31-1.21) | 0.163 | 0.307 | 4.0 | F |
| Asian | 4 | 456/895 | 1.66 (0.84-3.30) | 0.148 | 0.454 | 0.0 | F |
| ESCC | 5 | 547/1319 | 1.36 (0.76-2.45) | 0.297 | 0.480 | 0.0 | F |
| EADC | 2 | 314/676 | 0.58 (0.28-1.24) | 0.160 | 0.328 | 0.0 | F |
| PB | 5 | 805/1476 | 1.10 (0.67-1.80) | 0.704 | 0.312 | 16.1 | F |
| HB | 1 | 56/95 | 0.23 (0.03-1.91) | NA | NA | NA | NA |
EPHX1: Microsomal epoxide hydrolase; OR: Odds ratio; R: Random-effects model; F: Fixed-effects model; ESCC: Esophageal squamous cell carcinoma; EADC: Esophageal adenocarcinoma; PB: Population-based controls; HB: Hospital-based controls; NA: Not available.