Figure 6.

In vitro validation for a previously reported AGO-associated motif. (A) The previously reported G-rich motif was able to be replicated using MEME from the original data (Dicer^−/− mutant from mouse embryonic cells, two biological replicates, Dicer^−/− replication 1 and 2). (B) The G-rich motifs received the lowest RNAcompete scores for human AGO2 (sharing ∼99.1% protein sequence similarity with mouse) in comparison with all probes on the RNAcompete array and also with the AGO motif in this study. (*) P < 1 × 10⁻⁵⁰, Wilcoxon rank sum test.