Figure 1. Genome-wide analysis of 875,967 SNPs in 12 cases of SCLS and 18 control subjects. (A) Manhattan plot showing negative log-transformed P values of the case-control allele frequency significance on the y-axis. The color scale of the x-axis denotes chromosome numbers. Gene names associated with individual dots indicate SNPs of greatest significance or with potential disease relevance. (B) Distribution of 653 SNPs meeting the established criterion for genome-wide significance (P ≤ 1 × 10−3, Chi square test). (C) Expanded view of chromosomes 6–7, which contain regions of neighboring SNPs highly associated with SCLS.