Figure 2. Functional enrichment of SCLS-associated SNPs. (A, B) 2-D heat maps representing genes containing SNPs significantly associated with SCLS and their associated functional annotation terms, as determined by the DAVID software algorithm. Related genes are portrayed on the x-axis and their corresponding annotations on the y-axis. Green areas represent positively reported gene-term association whereas black areas denote no gene-term association yet reported. Functionally enriched categories related to endothelial barrier dysregulation in SCLS included “cell projections” (A) and “cell adhesion” (B).