Table 1.
Sesquiterpine lactones, tetracyclic sesterpenoids and sesterterpenes.
| # | Location and/or name | IC50 (µM) | Properties |
|---|---|---|---|
| 1 | Guaianolide | ~60 | |
| 2 | Germacranolide | ~40 | |
| 3 | Guaianolide | ~40 | |
| 4 | Eudesmanolide: MEGxm0_000041 | ~60 | Cytotoxic to L5178Y lymphoblastic, PC12 neuroendrocrine, HeLa cervical cancer cells [52] |
| 5 | Tagitinin C | ~10 | Anti-malaria [53] |
| 6 | Parthenolide | >100 | Anti-tumor, anti-inflammatory [40,45,46] |
| 7 | 17-C4 | ~30 | |
| 8 | 16-H2 | ~10 | |
| 9 | Helenalin | ~80 | Inhibition of NF-κB and suppression of Bcl-2-mediated resistance to apoptosis [47]; anti-leukemic [54]; inhibition of telomerase [49]; induction of autophagy and cell cycle arrest [55] |
| 10 | Luffariellolide | ~10–20 | Cytotoxic, inhibits HIF-1α [50] |
| 11 | Scalaradial, 12-epi- | ~40–60 | Inhibits EGFR activation of Akt independent of PLA2 [51] |