Table 4.
Chalone compounds.
| # | Location and/or name | IC50 (µM) | Properties |
|---|---|---|---|
| 39 | Phloretin | ~35–90 | Induction of apoptosis in breast cancer cells via Bcl-xL degradation [89]. |
| 40 | Curcumin | ~70 | Anti-proliferative, anti-tumor, anti-inflammatory via suppression of NF-κB activation [90]; reported Hsp90 inhibitor [91]. |
| 41 | 2',4-Dihydroxychalone | ~120 | |
| 42 | [6-methyl-5, 7-dihydroxy-2,2-dimethylchromen-8-yl]-3-phenylprop-2-en-1-one Similar to rotterlin and catechin | ~60 | |
| 43 | (CID 193568) Corylifolinin; isobacachalone | ~50 | Inhibition of LPS-induced NO production [92]. |
| 44 | Dimethyl cardamonin (CID 10424762) | ~70 | Antibacterial; anti-fungal [93,94]; anti-proliferative via cell cycle arrest; anti-inflammatory via blocking NF-κB activation [95,96,97,98]. |
| 45 | Nordihydroguaiaretic acid | ~35–80 | Phase II study for effect on prostate cancer. Increased doubling time of PSA. Thought to inhibit IGF1R and HER2 [99]. Repressed breast tumor growth via mTORC1 inhibition [100]. |
| 46 | Violastyrene | ~20 | |
| 47 | Rottlerin | ~60 | Anti-proliferative [101,102]; cytotoxic to pancreatic cancer cells via PI3K/Akt/mTOR inhibition [103]; inhibits NF-κB; STAT and amyloid aggregation [104]. |