Table 6.
Alkaloid compounds.
| # | Location and/or name | IC50 (µM) | Properties |
|---|---|---|---|
| 51 | Peganine (CID 72610) | ~130 | Modest anti-proliferative and cytotoxic activity [108]; anti-mycobacterial [109]; anti-leishmania [110,111]. |
| 52 | Gliotoxin acetate (CID 21127802) | ~15 | Anti-viral; anti-mycobacterial; inhibition of NF-κB; anti-leukemic; anti-tumor [112,113,114]. |
| 53 | 19-A7: (Z)-4-isopropyl-1-(2-methylpropylidene)-1,2-dihydro-6H-pyrazino[2,1-b]quinazoline-3,6(4H)-dione | ~60 | |
| 54 | (+)-Cinchonine | ~30 | Circumvention of P-glycoprotein mediated multi-drug resistance [115]. |
| 55 | (2S,3R,3aS,9aR)-2-(hydroxymethyl)-6-imino-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5]oxazolo[3,2-a] pyrimidin-3-ol | ~50 | |
| 56 | (−)-Eseroline | ~50–90 | |
| 57 | Metacycloprodigiosin; Streptorubin | ~10 | Cytoxic activity against cancer cell lines [116,117]. |
| 58 | Fredericamycin | ~3 | Cytotoxic, anti-bacterial, anti-fungal, anti-tumor activities; topoisomerase inhibitor; cell cycle arrest [118,119]. |
| 59 | Tryptanthrin | ~15 | Induced apoptosis in human leukemia cells; suppression of NO production [120]. |