Table 7.
Benzylisoquinoline Alkaloids.
| # | Location and/or name | IC50 (µM) | Properties |
|---|---|---|---|
| 60 | Sanguinarine | ~70 | Induces cell cycle arrest and apoptosis in human cervical cancer cells [128]; anti-inflammatory [129]; anti-fungal [130]. |
| 61 | 3-hydroxymethyl-glaucine | ~80 | |
| 62 | Thaliporphine; thalicmidine | ~9 | Inhibits the activity of LPS-induced NOS; inhibits LPS-induced nuclear translocation of NF-κB [131]. |
| 63 | Isoboldine | ~30–80 | Anti-viral [121]. |
| 64 | Bracteoline | ~80 | |
| 65 | 7-oxoglaucine | ~80 | Anti-plasmodial [132]; anti-inflammatory [133]. |
| 66 | 7-Formyl-dehydroglaucine | ~1–3 | |
| 67 | Dehydroglaucine | 0.9 | Anti-microbial, some anti-fungal activity [126]. |
| 68 | Dehydroglaucine dimer | 0.1–0.4 | |
| 69 | Glaucine derivative | >30 | |
| 70 | Dehydroglaucinylphenone | ~7–20 | |
| 71 | Berberine | ~40 | Anti-tumor, anti-metastatic, inhibits HIF1α [129,134,135,136]. |
| 72 | 3-Formyl-glaucine | ~8–20 | |
| 73 | Dihydrosanguinarine derivative | ~40 | Anti-fungal [130]. |