Table 9.
Quinones.
| # | Location and/or name | IC50 (µM) | Properties |
|---|---|---|---|
| 78 | Vineomycin A1 | ~100 | |
| 79 | β-Lapachone (CID 3885) | ~20 | Anti-cancer; anti-trypanosomal activity; anti-viral [147,148,149,150,151,152,153,154,155]. |
| 80 | Streptonigrin (CID 5351165) | ~15 | Disrupts NF-κB activation; antibacterial, antifungal, antiviral, anti-glioma [156,157,158,159,160,161]. |
| 81 | 15.16-Dihydrotanshinone | ~80 | Anti-cancer; inhibition of HIF-1α; depletion of Bcl-2 [162,163,164]. |
| 82 | 2-A5: 1,4-Napthoquinone derivative | ~10 | |
| 83 | 30-D10: 9,10-Anthraquinone derivative | ~2 | |
| 84 | Plumbagin | <0.05 | Widely studied anti-cancer activity; reported to target EGFR, STAT-3, Akt, and NF-κB pathways [165,166]. |
| 85 | 7-[8-formyl-6,7-dihydroxy-3-methyl-5-(methylethyl)-1,4-dioxo(2-naphthyl)]-2,3- dihydroxy-6-methyl-4-(methylethyl)-5,8-dioxonaphthalenecarbaldehyde | ~6 | |
| 86 | 1,2,4-trihydroxyanthracene-9,10-dione | ~40–100 | |
| 87 | Tetrangulol G2 | ~20 | |
| 88 | Dihydodaunomycinone; Leukaemomycin-D | >60 | |
| 89 | 3-Formyl Rifamycin SV | ~15–35 | Inhibition of Vaccinia virus assembly [167]. |
| 90 | Shikonin | ~75 | Anti-inflammatory, anti-tumor, and wide-ranging activities reported [166,168]. |
| 91 | Herbimycin | ~40 | Hsp90 inhibitor [1,169,170,171]. |
| 92 | Dalbergione | ~2 | |
| 93 | 4'-Methoxydalbergione | ~5 | Anti-trypanosomal [172]. |
| 94 | 3'4'-Dimethoxydalbergione | ~5 | Anti-trypanosomal [172]. |