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. 2012 Jul 26;1(2):222–244. doi: 10.3390/biology1020222

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© 2012 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Comparison of the first 15 ANM modes generated from the apo HIV-1 RT structure and those of the NVP and EFV bound enzyme using the 1DLO, 1RTH and 1FK9 crystal structures respectively. The matrices show the pairwise correlation of modes, the darker the square the higher the magnitude of the correlation. (a) The apo to NVP bound and (b) apo to EFV bound comparisons show similar patterns with high correlations between the first and third modes and lower correlation in most other modes. (c) shows that the modes for the EFV and NVP bound structures are much more similar. The correlation of mode 2 for both structures with other modes indicates that this mode is not identical between the two structures.