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. 2012 Jul 26;1(2):222–244. doi: 10.3390/biology1020222

Figure 6.

Figure 6

Comparison of the first 15 ANM modes generated from different HIV-1 RT structures bound to NVP and EFV, using the 1RTH and 1VRT NVP bound structures and 1FK9 and 1IKW EFV bound structures. The matrices show the magnitude of the pairwise correlation of the modes, the darker the square the higher the correlation. (a) and (b) show comparisons of the modes generated from different crystal structures but with RT bound to the same inhibitor, NVP and EFV respectively. In (c) the 1IKW (EFV) and 1VRT (NVP) bound structures are compared, more of the low modes show high levels of similarity than in the plot for 1FK9 and 1RTH shown in Figure 2c.