Table 1.

The EFV and NVP bound HIV-1 RT crystal structures analysed by PCA are divided into two groups according to PC1, groups A and B. Group A corresponds to the structures in which p51 flexibility is linked to that of the p66 thumb by ANMs, no such link is observed in ANMs based on group B structures. The drug bound and major resistance associated mutations present in the structure are also listed.

PDB code	NNRTI	Resolution (Å)	Resistance Mutations	Citation
Group A: p51 flexible
LW0	NVP	2.80	T215Y	Chamberlain et al. [49]
LWC	NVP	2.62	M184V	Chamberlain et al. [49]
S1U	NVP	3.00	L100I	Ren et al. [50]
VRT	NVP	2.20	–	Ren et al. [51]
HND	NVP	2.50	K101E	Ren et al. [52]
HNY	NVP	2.50	E138K	Ren et al. [52]
FK9	EFV	2.50	–	Ren et al. [53]
IKV	EFV	2.00	K103N	Lindberg et al. [7]
IKW	EFV	3.00	–	Lindberg et al. [7]
Group B: p51 constrained
FKP	NVP	2.90	K103N	Ren et al. [53]
JLB	NVP	3.00	Y181C	Ren et al. [54]
JLF	NVP	2.60	Y188C	Ren et al. [54]
LWE	NVP	2.81	M41L, T215Y	Chamberlain et al. [49]
LWF	NVP	2.80	M41L, D67N, K70R, M184V, T215F, K219N	Chamberlain et al. [49]
RTH	NVP	2.20	–	Ren et al. [51]
S1X	NVP	2.80	V108I	Ren et al. [50]
FKO	EFV	2.90	K103N	Ren et al. [53]
JKH	EFV	2.50	Y181C	Ren et al. [54]