Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Dec 2;2(4):1411–1437. doi: 10.3390/biology2041411

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

Spot module characteristics: (a) The over-expression summary map collects all over-expression spots observed in the individual portraits into one map. Subtypes frequently showing the respective spots are indicated. (b) The over-expression spot map defines the spots used for further analysis. Regions beyond the 98th-percentile threshold of metagene expression are selected. The spots are assigned by large capital letters. The blue rectangles include highly correlated spots (r > 0.7). The blue and red dashed lines connect correlated (0.4 < r < 0.7) and anti-correlated (r < −0.6) spots, respectively. (c) The overexpression heatmap shows the mean expression of the spots across all samples in the data set. The samples are sorted according to their subtype. (d) The under-expression summary map collects all under-expressed spots observed in the individual portraits. Note the antagonistic nature of mBL and non-mBL expression: spots over-expressed in mBL become under-expressed in non-mBL and vice versa (compare with panel a).