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The effect of statins, fibrates and retinoic acid on the PPARα and RXRα-induced CAC gene expression. The binding of fibrates to PPARα, the activation by statins through the Rho-signaling pathway and the binding of retinoic acid to the dimer PPARα-RXRα are shown. The positions of the consensus sequences for FOXA2, Sp1, PPARα, BRE, and DPE in the CAC gene proximal promoter are also indicated.
