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. 2011 Feb 4;32(2):182–187. doi: 10.1038/aps.2010.210

Figure 1.

Figure 1

Chemical structures of NBP and basic properties of the TREK-1 channel. (A) Chemical structures of racemic dl-NBP and its optical isomers. (B) The transfection of CHO cells with TREK-1 channels hyperpolarized the membrane potential, from -17.6±4.0 mV (Wt/CHO, n=7) to -55.3±2.4 mV (TREK-1/CHO, n=25). Values are expressed as the mean±SEM; eP<0.05 vs Wt/CHO cells. (C) Electrophysiological verification of the presence of TREK-1 channels in transfected CHO cells. a: Current elicited from Wt/CHO cells after being depolarized to +80 mV from a holding potential of -80 mV. b: Current elicited from TREK-1/CHO cells. c: Activation of TREK-1 currents by AA.