Skip to main content
. 2011 Feb 4;32(2):182–187. doi: 10.1038/aps.2010.210

Figure 2.

Figure 2

Effect of NBP isomers on TREK-1 channel currents. (A) Whole-cell ramp currents as a function of membrane potential before, during and after application of (a) 10 μmol/L l-NBP (n=8), (b) 10 μmol/L dl-NBP (n=9) and (c) 10 μmol/L d-NBP (n=9). (d) Whole-cell ramp current recording protocol. The currents were evoked from a holding potential of -80 mV by ramping the membrane potential from -80 mV to +60 mV over 400 ms. (B) Comparison of the inhibition rates of TREK-1 currents by NBP isoforms (l-NBP n=8, dl-NBP n=9 and d-NBP n=9) measured at +60 mV using TREK-1/CHO cells. The currents were evoked from a holding potential of -80 mV, and the membrane was ramped from -80 mV to +60 mV over 400 ms. Values are expressed as percentages of the control (means±SEM); eP<0.05 vs dl-NBP group.