Skip to main content
. 2011 Feb 4;32(2):167–174. doi: 10.1038/aps.2010.191

Table 2. The neuronal damage scores for normothermic rats, vehiclet-reated heatstroke rats, and KYNA-treated heatstroke rats. bP<0.05, compared with group 1; eP<0.05, compared with group 2.

Treatment groups Neuronal damage score (0–3)
Normothermic rats 0 (0, 0)
Vehicle-treated heatstroke rats 2 (2, 2)b
KYNA (30 mg/kg, iv)-treated heatstroke rats 1 (0.25, 0.75)e
KYNA (100 mg/kg, iv)-treated heatstroke rats 0 (0, 0)e

Values represented the median with the first and third quartile in parentheses of 6 rats per group. For determination of neuronal damage score, heatstroke rats were killed 85 min after the start of heat stress, whereas the normothermic rats were killed 480 min after the start of heat exposure (or at the experiment end). All heatstroke rats which had heat exposure (43 °C) were withdrawn exactly at 68 min and then allowed to recover at room temperature (26 °C). The data were evaluated by a Wilcoxon signed rank test followed by the Duncan test when appropriate.