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. 2011 Jun 3;32(6):798–804. doi: 10.1038/aps.2011.34

Figure 1.

Figure 1

Schematic of (A) lamin gene (LMNA) and (B) lamin A/C protein. * indicates alternate splicing in exon 10 giving rise to the proteins lamin A (664 amino acids) and lamin C (572 amino acids). Shown are several mutations known to result in laminopathies with corresponding amino acid or nucleotide changes. 1=Emery-Dreifuss muscular dystrophy; 2=Limb girdle muscular dystrophy type 1B; 3=dilated cardiomyopathy; 4=Charcot-Marie Tooth type 2B1; 5=Familial partial lipodystrophy of the Dunnigan-type; 6=Hutchison-Gilford progeria syndrome.