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Schematic of the domain structure of a KATP channel. Four Kir6.2 subunits form the channel pore, and are surrounded by four sulfonylurea receptors (SURs) that regulate pore activity. Each Kir6.2 subunit has two domains (TM1 and TM2), linked by an extracellular pore-forming region (H5). Each SUR subunit has 17 transmembrane regions grouped into three domains: TMD0 (TM1-5), TMD1 (TM 6-11), and TMD2 (TM 12-17). Each SUR subunit also has two nucleotide binding domains (NBD).
