. Author manuscript; available in PMC: 2014 May 5.

Published in final edited form as: Expert Opin Investig Drugs. 2013 Feb 21;22(4):443–462. doi: 10.1517/13543784.2013.772979

Table 3. GEM models of NF-associated clinical problems.

NF1
Memory and learning deficits	Nf1 +/− mice	[93]
	Nf1^fiox/mut; GFAP-Cre mice	[94]
Attention deficit	Nf1 +/− mice	[93]
	Nf1^fiox/mut; GFAP-Cre mice	[95]
	Nf1^fiox/wt; Syn1-Cre mice	[96]
	Nf1^fiox/wt; Dix6-Cre mice	[96]
Optic glioma	Nf1^flox/mut; GFAP-Cre	[63,64]
	Nf1 +/−; LSL-KRas; GFAP-Cre mice	[97]
Malignant glioma	Nf1^flox/flox. p53^flox/flox; pten^flox/flox mice	[98]
	Nf1^flox/flox; p53^flox/flox mice	[99]
Dermal neurofibroma	Nf1^flox/mut; PLP-Cre^ER mice	[100]
Plexiform neurofibroma	Nf1^flox/flox; Dhh-Cre mice	[101]
	Nf1^flox/flox; plp-Cre mice	[100]
	Nf1^flox/mut; Krox20-Cre mice	[61]
Malignant peripheral nerve sheath tumor	Nf1 +/−; p53+/− mice	[102,103]
Long bone abnormalities	Nf1^flox/flox; Prx1-Cre mice	[104]
	Nf1^flox/mut mice + Cre	[105]
	Nf1^flox/flox; Col2α1-Cre mice	[106]
Skeletal abnormalities	Nf1^flox/mut; Col2.3-Cre mice	[107]
Leukemia	Nf1^flox/flox; Msx1-Cre mice	[108]
Pheochromocytoma	Nf1 +/− mice	[109]

NF2

Schwannoma	Nf2^flox/flox mice +Ad-Cre	[110]
	Nf2^Δ39-121; P0-Cre mice	[111]
Meningioma	Nf2^flox/flox; PGDS-Cre mice	[112]
	Nf2^flox/flox mice +Ad-Cre	[113]
Ependymoma	None to date
Mesothelioma	Nf2^flox/flox; p16^flox/flox mice +Ad-Cre	[114]
	Nf2^flox/flox; p53^flox/flox mice +Ad-Cre	[114]
Cataracts	Nf2^flox/flox mice +Ad-Cre	[110]
Neuropathy	Nf2^exon16 knockout mice	[115]

GEM: Genetically engineered mouse; NF: Neurofibromatosis.