Comparison of ATFX concentrations in plasma after an oral dose of ATFX alone (open circle) and co-administration of TP (filled circle). For TP, on d 1 and 5, 200 mg of TP was given to subjects as a single morning dose, and on d 2 to 4, 400 mg of TP was given to subjects twice daily (morning dose and evening dose). For ATFX, on d 1, 400 mg was given to subjects as a single morning dose, and on d 2 to 5, 200 mg of ATFX was given to subjects once daily (morning dose). The results are expressed as the mean±SD (n=12).