Table 3. Inhibitory effect of ATFX on TP metabolites in human liver microsomes in vitro. Data represent mean±SD of three experiments.
KI (μmol/L) | Kapp,i (μmol/L) | kinact,i (min−1) | kinact,i/Kapp,i (×10−5) (min−1·M−1) | |
---|---|---|---|---|
3-MX | 1209.2±66.3 | 265.88±18.81 | 0.0097±0.0016 | 3.68±0.84 |
1-MX | 1033.2±78.9 | 353.29±16.20 | 0.0073±0.0012 | 2.06±0.37 |
1,3-DMU | 1519.4±56.6 | 430.21±14.19 | 0.0047±0.0080 | 1.08±0.15 |