Table 2. Frequency of micronucleus in bone marrow of mice after acute and subchronic treatments with aripiprazole.
| Groups | Acute treatment MNPCE in 2000 PCE mean±SD | Subchronic treatment MNPCE in 2000 PCE mean±SD |
|---|---|---|
| Saline | 1.14±0.38 | 1.15±0.37 |
| Tween | 1.20±0.45 | 1.86±1.60 |
| Aripiprazole 1 mg/kg | 1.80±1.79 | 1.43±1.90 |
| Aripiprazole 3 mg/kg | 2.25±1.50 | 1.40±0.89 |
| Aripiprazole 10 mg/kg | 1.40±0.89 | 2.86±2.49 |
| Positive control | 10.0±5.29c | – |
n=5 animals per group. Positive control: cyclophosphamide (25 mg/kg). MNPCE: micronucleated polychromatic erythrocytes (PCE). cP<0.01: statistically significant difference from the saline group (ANOVA Tukey's test).