. 2011 Sep 19;32(10):1294–1302. doi: 10.1038/aps.2011.90

Table 4. Pharmacokinetic parameters of tacrolimus from self-microemulsifying gastricretentive sustained release tablets and commerical capsules.

No	Order of administration	AUC_(0–t) (ng·h·mL⁻¹)		AUC_(0–∞) (ng·h·mL⁻¹)		t_max(h)		C_max (ng·mL⁻¹)		F%
No	Order of administration	SEGT^a	CC^b	SEGT	CC	SEGT	CC	SEGT	CC	F%
1	SMEGSRT/CC	88.20	28.54	126.22	40.56	4	1	6.61	4.82	309.0
2	SMEGSRT/CC	206.91	18.67	252.52	25.68	8	1	11.54	2.50	1107.8
3	SMEGSRT/CC	74.48	43.99	85.39	68.74	6	1	6.02	5.01	169.3
4	CC/SMEGSRT	209.91	32.11	320.47	48.21	10	1	11.23	3.98	653.7
5	CC/SMEGSRT	82.73	26.21	103.03	35.65	4	1	7.80	3.47	315.6
6	CC/SMEGSRT	194.35	25.41	265.86	33.14	8	1	9.96	2.88	764.9
	Mean	142.76	29.16	192.25	42.00	6.67	1	8.86	3.78	553.4
	SD	67.12	8.51	99.23	15.10	2.42	0	2.38	1.02	353.8

^aSMEGSRT self-microemulsifying gastricretentive sustained release tablets.

^bCC commercial capsules.