Table 1. Subject demographics.

	All MS	MSmild (baseline SR-EDSS 0 – 3.5)	MSmoderate (baseline SR-EDSS 4.0 – 5.5)	Controls
N	27, all RRMS	13	14	18
Average age, years (range)	41 (24 – 67)	40 (24-67)	41 (26-59)	34 (27 – 60)
Female, %	67	69	64	78
BMI, average	26	24	28	23
Caucasian race, %	93	92	93	89
Disease duration mean/median (range), years	10 / 5 (0-46)	10 / 7 (0 – 33)	13 / 8 (1 – 46)	NA
On disease modifying therapy, %	59	77	43	NA
Patient-reported relapses, n	8	1	7 (2 subjects with 2 relapses each)	NA
Baseline SR-EDSS mean/median (range, 0-10)	3.3 / 4.0 (0 - 5.5)	2.2 / 2.0 (0 – 3.5)	4.3 / 4.0 (4.0 – 5.5)	NA
18 month SR-EDSS mean/median (range, 0-10)	3.1 / 4.0 (0 – 6.0)	2.0 / 2.0 (0 – 4.0)	4.1 / 4.0 (2.5 – 6.0)	NA
18 month change in SR-EDSS Mean (range)	-0.24 (-2.5 to 2.0)	-0.21 (-2.0 to +1.5)	-0.27 (-2.5 to +2.0)	NA

BMI, body-mass index; RRMS, relapsing remitting multiple sclerosis; SR-EDSS, self-rated Expanded Disability Status Scale