Figure 1. SRT1720 extends lifespan and improves health in mice fed a standard diet.
(A) Kaplan-Meier survival curves for mice fed either a standard diet (SD) or high-fat diet (HFD) supplemented without or with SRT1720 (SD-SRT1720, HFD-SRT1720); (B) Average body weight over the study; (C) Average daily caloric intake over the study; (D) Percentage fat mass measured by nuclear magnetic resonance spectroscopy at 13 months of age; (E) Respiratory Exchange Ratio (RER); (F) Rotarod performance. Data are shown as mean ± SEM. * p≤0.05 compared to diet without SRT1720.