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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Alcohol Clin Exp Res. 2014 Mar 3;38(5):1216–1226. doi: 10.1111/acer.12373

Figure 1.

Figure 1

Dietary cholesterol protects against alcohol-induced pial arteriole in vivo constriction independently of EtOH elimination rate from the systemic compartment. (A) Screenshots of brain surface obtained through a closed cranial window. Vertical dashed lines highlight external diameter of pial arteriole. Pial arteriole diameter was monitored before (left) and after (middle) a 50 mM EtOH infusion into cerebral circulation via catheter in carotid artery. Washout of EtOH was achieved by infusion of sodium saline (right). (B) Averaged data show a significant decrease in pial arteriole diameter (PAD) in response to EtOH in rats on high-cholesterol diet (n=4) compared to control group (n=4). *p<0.05, when compared to EtOH-induced arteriole constriction in control group. (C) Averaged blood alcohol levels after infusion of 50 mM EtOH into cerebral circulation of rats on control vs. high-cholesterol diet. Data show lack of significant differences between the groups throughout 7 min following EtOH infusion. Each data point was obtained from ≥4 animals.