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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Alcohol Clin Exp Res. 2014 Mar 3;38(5):1216–1226. doi: 10.1111/acer.12373

Figure 3.

Figure 3

Dietary cholesterol protects against alcohol-induced cerebral artery constriction (AICAC) in absence of a functional endothelium. Diameter traces from isolated, de-endothelialized and in vitro pressurized middle cerebral artery of rat on control (A) vs. high-cholesterol (B) diet. (C) Averaged diameter data from de-endothelialized arteries in response to endothelium-dependent (1 µM carbachol) vs. endothelium-independent (1 µM sodium nitroprusside) vasodilators. Here and in (D), each point represents the average of ≥3 arteries, each artery harvested from a different rat. *p<0.05, when compared to sodium nistroprusside. (D) Averaged data show a protective effect of dietary cholesterol against AICAC in isolated de-endothelialized arteries. *p<0.05, when compared to arteries from rats on control diet.