Table 2.
Enzymatic ligation of selected tRNASec variants.
| tRNA mimic[a] | Mwcalcd | Mwobs[d] | Yield[e] [nmol] |
|---|---|---|---|
| Abu(p)-tRNASec (90 nt)[b] | 29095 | 29096 | 1.0 |
| Abu(p)-tRNAU1ASec (93 nt)[c] | 30028 | 30028 | 0.5 |
| Ser(p/NαCH3)-tRNASec (93 nt)[c] | 30044 | 30043 | 4.0 |
For sequences see Figure 2.
Ligation of 38, 33, and 19 nt long fragments.
Ligation of 39, 35, and 19 nt long fragments.
Measured by LC-ESI mass spectrometry.
Yield of purified, isolated tRNA.