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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Nat Methods. 2014 Feb 16;11(4):429–435. doi: 10.1038/nmeth.2845

Figure 3. Cellular modification induced by TALENs at on-target and predicted off-target genomic sites.

Figure 3

(A) For cells treated with either no TALEN or CCR5A TALENs containing heterodimeric EL/KK, heterodimeric ELD/KKR, or the homodimeric (Homo) FokI cleavage domain variants, cellular modification rates are shown as the percentage of observed insertions or deletions (indels) consistent with TALEN cleavage relative to the total number of sequences for on-target (On) and predicted off-target sites (Off). See the main text for details. ND refers to no data collected since the cellular modification of off-target sites OffC-38, OffC-49, OffC-69 and OffC-76 was not assayed for CCR5A TALENs containing EL/KK and ELD/KKR FokI domains. (B) Same as (A) for ATM TALENs. For (A) and (B) sample sizes and P-values are given in Supplementary Tables S7 and S9.