. Author manuscript; available in PMC: 2014 May 5.

Published in final edited form as: Biol Blood Marrow Transplant. 2012 May 27;18(11):1677–1686. doi: 10.1016/j.bbmt.2012.05.011

Table 3.

Toxicities per dose level (2-dose schedule)

Level	N	Gem infusion (min)	Gem dose (mg/m²)	Mucositis		Skin		DLT
Level	N	Gem infusion (min)	Gem dose (mg/m²)	G2	G3	G2	G3	DLT
1	3	15	225	33%	0	0	0	0%
2	3	40	475	0	0	0	0	0%
3	3	60	675	33%	0	0	0	0%
4	6	90	975	80%	0	0	0	0%
5	14	120	1,275	59%	23%	12%	0	6%
6	22	180	1,875	71%	6%	18%	0	2%
7	14	210	2,175	60%	27%	33%	0	7%
8	14	240	2,475	64%	28%	21%	7%	7%
9 (MTD)	50	270	2,775	54%	28%	18%	3%	14%