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. Author manuscript; available in PMC: 2014 May 5.
Published in final edited form as: Annu Rev Biochem. 2012;81:65–95. doi: 10.1146/annurev-biochem-051710-134100

Table 1.

Subunit composition and biological activities of COMPASS family from yeast to human.

ySet1/COMPASS Drosophila COMPASS/COMPASS-like Complexes Mammalian COMPASS/COMPASS-like Complexes Biological Activities
Set1 Set1; Trx; Trr Set1A/B; MLL1-4 The catalytic subunits
Cps60 (Bre2) Ash2 Ash2 Required for H3K4me3
Cps50 (Swd1) dRbbp5 dRbbp5 Required for assembly
Cps40 (Spp1) dCxxC1 CxxC1 Components of Set1 complexes
Cps35 (Swd2) dWdr82 Wdr82
Cps30 (Swd3) Wds Wdr5 Required for assembly
Cps25 (Sdc1) Dpy30 Dpy30 Required for H3K4me2/3
HCF1 HCF1 Components of Set1 complexes
graphic file with name nihms546243t1.jpg graphic file with name nihms546243t2.jpg Trx and MLL1/2 specific
PTIP; PA1; NCOA6; UTX PTIP; PA1; NCOA6; UTX Trr and MLL3/4 specific