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. 2014 May 1;30(5):468–475. doi: 10.1089/aid.2013.0197

FIG. 4.

FIG. 4.

Peptide binding and stability influence antiviral activity and HIV selection pressure. (A) Viral load setpoints for HLA-B*07:02-positive individuals with C-clade infection making IFN-γ ELISpot response to Gag OLP-48 (ACQGVGGPSHKARVLAEA), which contains only p24-GL9, compared to individuals not making this response; (B) selection of Gag-357G HIV sequence polymorphism in two large B-clade and C-clade cohorts; (C) p24 Gag-GL9-3S and GL9-3G peptides tested for binding half-life and (D) affinity to the HLA-B*07:02 molecule.