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. 2011 Oct 10;32(12):1529–1536. doi: 10.1038/aps.2011.109

Figure 6.

Figure 6

Crocetin sensitizes cancer cells to vincristine-induced cytotoxicity. (A) HeLa, A549, and SKOV3 cells were treated with crocetin (60 μmol/L) or VCR (1 nmol/L) separately or in combination for 72 h. Cell death was detected using the LDH assay. (B) The vincristine-resistant breast cancer cell line (MCF-7/VCR) was treated with crocetin (60 μmol/L) or VCR (1 μmol/L or 2 μmol/L) separately or in combination for 72 h. Cell death was measured using the LDH assay. n=3. Mean±SD. cP<0.01 vs crocetin alone, fP<0.01 vs VCR alone.