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. 2011 Oct 10;32(12):1475–1482. doi: 10.1038/aps.2011.120

Figure 2.

Figure 2

Wogonin prevented palmitate-induced apoptosis. VSMCs were cultured in serum-free medium for 6 h and treated with or without 0.75 mmol/L of palmitate for 12 h, followed by a second treatment with or without 10, 25, and 50 μmol/L of wogonin for an additional 12 h (A and C) or 25 μmol/L of wogonin for 6, 12, and 24 h (B and D). (A and B) The effects of wogonin on the percentage of apoptotic cells. Apoptotic cells were visualized using TUNEL methods. eP<0.05; fP<0.01 compared with the palmitate-treated group. (C and D) The effects of wogonin on cleaved caspase-3 and caspase-6 expression. In total, 5 μg/mL of tunicamycin (18 h) was used as a positive control. The expression levels of cleaved caspase-3 and caspase-6 were detected using Western blotting. The figures are representative of at least three independent experiments with similar results.