Table 2. Pharmacokinetic parameters of L-threonate in healthy Chinese subjects following single oral administration (mean±SD).
| Dose (mg) | ||||
|---|---|---|---|---|
| 675 (n=12) | 2025 (n=12) | 2025 (fed) (n=12) | 4050 (n=12) | |
| tmax (median, h) | 2.0±0.5 | 2.0±0.4 | 3.0±0.5 | 2.0±0.7 |
| Cmax (mg/L) | 15.5±4.6 | 32.3±9.9 | 39.1±12.0 | 42.8±15.1 |
| t1/2 (h) | 2.4±1.3 | 2.7±0.8 | 2.3±0.4 | 2.7±0.6 |
| AUC0–t (mg/L·h) | 76.2±30.1 | 150.1±41.8 | 199.7±69.5 | 218.3±90.8 |
| AUC0–∞ (mg/L·h) | 77.7±30.7 | 152.9±42.9 | 203.6±70.4 | 220.9±90.0 |
| Vz/F (L) | 28.9±6.0 | 53.6±14.8 | 37.4±13.6 | 76.5±22.4 |
| Cl/F (L/h) | 9.8±3.3 | 14.5±4.9 | 11.4±4.9 | 21.3±8.7 |
| Cl/r (L/h) | 1.0±0.7 | 0.7±0.5 | 0.7±0.3 | 0.8±0.5 |
| Au0–t (mg) | 69.8±48.2 | 84.6±75.7 | 132.8±62.4 | 135.5±136.6 |
| Urinary excretion rate (%) | 10.30 | 4.20 | 6.60 | 3.30 |
BMI*: body mass index