Table 3. 90% CI for the ratio of dose-normalized, geometric mean values of AUC and C_max.

	90% CI
	AUC0–t		Cmax
	Mean*	90% CI+	Mean*	90% CI+
675 mg: 2025 mg	1.486	1.276–1.697	1.441	1.300–1.582
4050 mg: 2025 mg	0.701	0.491–0.912	0.658	0.517–0.800
CVw (%)#	30.50%	20.25%

CI=(A−B)(+/−)t_value^*sqrt(MSE)^*sqrt(1/nA+1/nB), where A−B=mean difference between the treatment A and B under log scale, t_value is the crirical values from t-distribution with degree of freedom of MSE, CVw%(within–subject coefficients of variation)=sqrt(exp(MSE)−1)^*100, where MSE is the residual error from ANOVA).

(^*)=geometric mean

(+): lower limit-upper limit

(#): within-subject coefficients of variation=sqrt[exp(MSE)–1]×100, where MSE is the residual error from ANOVA