The protein levels of TGF-β1, CTGF and BMP-7 in sham mice (a), UUO mice (b) and VEGF-treated mice (c) at d 3, 7, and 14, respectively. (A) Representative western blot of TGF-β1, CTGF and BMP-7 in sham and UUO mice treated with or without VEGF. (B) Compared with UUO group, VEGF treatment significantly inhibited the expressions of TGF-β1 and CTGF and increased BMP-7 expression. Results were shown as ratio of optical density for TGF-β1, CTGF, or BMP-7 to that of β-actin and presented as mean±SD of 3 independent experiments. bP<0.05 vs respective sham mice; eP<0.05 vs respective UUO mice.