Table 3. CYP2C9 allele frequencies in East Asian populations.
Populations | n | CYP2C9 allele frequency | Reference | |||
---|---|---|---|---|---|---|
*1 | *2 | *3 | *13 | |||
Korean | 4308 | 0.949 (0.942–0.956) | 0.000 (0.000–0.000) | 0.046 (0.040–0.052) | 0.005 (0.003–0.007) | Present study# |
Chinese | 2174 | 0.964 | 0.000 | 0.036 | ND | 14 |
1008 | 0.967 | 0.000 | 0.033 | ND | 15 | |
788 | 0.963 | 0.001 | 0.036 | ND | 16 | |
400 | 0.975 | 0.000 | 0.025 | ND | 8 | |
338 | 0.967 | 0.000 | 0.033 | ND | 17 | |
230 | 0.983 | 0.000 | 0.017 | ND | 18 | |
204 | 0.951 | 0.000 | 0.049 | ND | 19 | |
796 | 0.958 | 0.001 | 0.041 | ND | 9 | |
658 | - | - | - | 0.006 | 20 | |
294 | - | - | - | 0.010 | 21 | |
Sum of Chinese | 5938(952)* | 0.964 (0.959–0.969) | 0.003 (0.002–0.004) | 0.035 (0.030–0.040) | 0.007 (0.003–0.011) | |
Japanese | 1000 | 0.966 | 0.000 | 0.034 | ND | 9 |
1448 | 0.968 | 0.000 | 0.032 | ND | 22 | |
1200 | 0.979 | 0.000 | 0.021 | ND | 23 | |
524 | 0.968 | 0.000 | 0.031 | 0.002 | 10 | |
436 | 0.979 | 0.000 | 0.021 | ND | 24 | |
400 | 0.965 | 0.000 | 0.035 | ND | 8 | |
280 | 0.982 | 0.000 | 0.018 | ND | 25 | |
236 | 0.970 | 0.000 | 0.030 | ND | 26 | |
246 | 0.955 | 0.000 | 0.045 | ND | 27 | |
294 | 0.993 | 0.000 | 0.007 | ND | 28 | |
Sum of Japanese | 6064 (524)& | 0.972 (0.968–0.976) | 0.000 (0.000–0.000) | 0.028c (0.024–0.032) | 0.002 (0.000–0.005) |
Values in parentheses represent 95% confidence intervals; n=number of alleles; differences between frequency data were calculated using the chi-square test. ND=Not determined.
#, Data were combined with a previous study5.
*,&, Values in parentheses represent the total numbers with the CYP2C9*13 allele.
cP<0.01 between present study and sum of Japanese (95% CI on the difference 0.010–0.026).