Table 2.
Primary and secondary endpoints mean (SD) at three-months follow-up, change from baseline, and estimated treatment effect with 95% confidence interval.
| Covariate | N | Exenatide 3 mo. | Control 3 mo. | Exenatide Δ | Control Δ | Estimate (95% CI) | P-value |
|---|---|---|---|---|---|---|---|
| % Change BMI | 22 | - | - | −2.90 (1.80) | −0.15 (3.20) | −2.70 (−5.02, −0.37) | 0.025 |
| BMI (kg/m2) | 22 | 39.64 (4.67) | 42.03 (6.95) | −1.18 (0.67) | −0.04 (1.23) | −1.13 (−2.03, −0.24) | 0.015 |
| Weight (kg) | 22 | 117 (14.85) | 122 (20.79) | −2.93 (2.48) | 0.32 (3.21) | −3.26 (−5.87, −0.66) | 0.017 |
| Waist (cm) | 22 | 126 (9.79) | 126 (13.45) | −2.04 (2.62) | −1.01 (5.57) | −0.98 (−4.60, 2.64) | 0.579 |
| Total Tissue Fat (kg) | 15 | 52.78 (9.50) | 60.95 (15.90) | −1.69 (2.41) | −0.65 (2.50) | −0.72 (−3.66, 2.23) | 0.606 |
| Visceral Fat Area (cm2) | 14 | 1420 (524.68) | 1548 (326.25) | −97.00 (191.22) | −18.17 (178.62) | −78 (−309, 153) | 0.473 |
| SBP (mmHg) | 22 | 116 (9.03) | 122 (7.90) | −5.50 (9.13) | 2.00 (13.43) | −6.36 (−13.46, 0.73) | 0.076 |
| DBP (mmHg) | 22 | 69.67 (5.42) | 66.50 (8.17) | −1.50 (9.76) | −0.50 (14.44) | 3.37 (−3.02, 9.76) | 0.283 |
| Heart Rate (BPM) | 22 | 77.25 (8.36) | 79.50 (8.95) | 2.00 (9.19) | 1.60 (11.96) | −1.57 (−9.34, 6.19) | 0.677 |
| Total-cholesterol (mg/dL) | 22 | 160 (19.36) | 176 (29.02) | 0.08 (13.01) | −6.60 (12.04) | 1.98 (−9.48, 13.44) | 0.722 |
| LDL-cholesterol (mg/dL) | 21 | 91.91 (22.65) | 107 (19.17) | −1.45 (9.96) | −7.50 (17.64) | 1.52 (−12.81, 15.86) | 0.826 |
| HDL-cholesterol (mg/dL) | 22 | 39.75 (5.61) | 39.20 (8.30) | −0.42 (4.08) | −3.00 (5.12) | 2.08 (−1.82, 5.99) | 0.278 |
| Triglycerides (mg/dL) | 22 | 128 (51.85) | 136 (48.98) | 2.83 (53.69) | 3.90 (44.41) | −4.71 (−45.14, 35.72) | 0.810 |
| Glucose (mg/dL) | 22 | 80.67 (9.76) | 83.90 (7.05) | 1.17 (8.19) | 4.60 (9.51) | −3.33 (−9.71, 3.05) | 0.288 |
| Insulin (mU/L) | 22 | 22.25 (13.07) | 22.80 (9.37) | −8.33 (18.81) | 0.67 (7.43) | −2.91 (−10.91, 5.10) | 0.455 |
| HbA1c (%) | 22 | 5.12 (0.26) | 5.24 (0.26) | −0.12 (0.16) | −0.01 (0.14) | −0.11 (−0.23, 0.01) | 0.072 |
To convert total-, LDL-, and HDL-cholesterol from mg/dL to mmol/L, multiply by 0.02586; for triglycerides, multiply by 0.01129; for glucose, multiply by 0.05551. To convert insulin from mU/L to pmol/L, multiply by 7.175.