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. 2014 Apr 3;53(16):2594–2604. doi: 10.1021/bi500182x

Figure 1.

Figure 1

Proteins (EGF, EGFR, and Grb2), EGFR component states, and protein–protein interfaces considered in our computational model. The EGFR ectodomain is taken to be free or bound to EGF. A cytoplasmic domain of EGFR, comprising the juxtamembrane region (JM) and kinase domain, is taken to be locked (i.e., unavailable for interaction) or freed (i.e., available for interaction). The C-terminal tail of EGFR is taken to contain, as a simplification, a single docking site for Grb2, which can be unphosphorylated (Y) and inactive or phosphorylated (pY) and active.