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. 2011 Nov 21;33(1):41–48. doi: 10.1038/aps.2011.133

Figure 4.

Figure 4

The effects of SalA on the expression levels of both total and phosphorylated Akt. (A) The time dependent effects of Ang II on Akt phosphorylation in HUVECs. Ang II (1 μmol/L) caused a time-dependent increase in phospho-Akt level, starting at 5 min post stimulation, with a maximal 1.96±0.09 fold basal after 15 min. Thereafter, phospho-Akt signaling decreased rapidly. (B) The effect of different doses SalA on phosphor-Akt. Ang II increased the level of phosphorylation of Akt, whereas pretreatment with SalA for 12 h downregulated phosphorylation of Akt in a dose-dependent manner. (C) The effect of different times SalA on phosphor-Akt. Ang II increased the level of phosphorylation of Akt, whereas SalA (3, 6, 12, and 24 h) down-regulated phosphorylation of Akt with in a time-dependent manner. Data represent means ±SEM. n=3. cP<0.01 vs Control. fP<0.01 vs Ang II.